ME/CFS in the Department of Medicine

Other Pathogens

Check back here frequently for new research on other pathogens that may be associated with Chronic Fatigue Syndrome

Other pathogens have been proposed as the etiologic agent of CFS including Parvovirus B19, the xenotropic murine leukaemia virus-related virus (XMRV), and many others. However, the XMRV link to CFS was de-discovered by a NIH multi-centered Study led by Dr. Ian Lipkin and with participation with our CFS Research team at Stanford. XMRV is not considered to be associated with CFS any longer.

Parvovirus B19

Parvovirus
  1. Kerr JR et al. Antibody to parvovirus B19 nonstructural protein is associated with chronic arthralgia in patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). (2010)
  2. Zhang L et al. Microbial infections in eight genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis. (2010)
  3. Kerr JR et al. Preexisting psychological stress predicts acute and chronic fatigue and arthritis following symptomatic parvovirus B19 infection. (2008)
  4. Devanur LD et al. Chronic Fatigue Syndrome. (2006)
  5. Kerr JR. Pathogenesis of parvovirus B19 infection: host gene variability, and possible means and effects of virus persistence. (2005)
  6. Kerr JR et al. Cytokines in parvovirus B19 infection as an aid to understanding chronic fatigue syndrome. (2003)
  7. Kerr JR et al. Successful intravenous immunoglobulin therapy in 3 cases of parvovirus B19-associated chronic fatigue syndrome. (2003)
  8. Kerr JR et al. Chronic fatigue syndrome and arthralgia following parvovirus B19 infection. (2002)

Xenotropic Murine Leukaemia Virus-related Virus (XMRV)

Below are some of the original papers published on XMRV. For up to date news on this pathogen, please see the CFIDS Association’s XMRV News page.

  1. A multicenter blinded analysis indicates no association between chronic fatigue syndrome/myalgic encephalomyelitis and either xenotropic murine leukemia virus-related virus or polytropic murine leukemia virus (2012)

  2. Retraction for Lo et al., Detection of MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors (2010)

  3. Lo SC et al. Detection of MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors. (2010)
  4. Switzer et al. Absence of evidence of xenotropic murine leukemia virus-related virus infection in persons with chronic fatigue syndrome and healthy controls in the United States. (2010)
  5. Groom HC et al. Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome. (2010)
  6. Erlwein O et al. Failure to detect the novel retrovirus XMRV in chronic fatigue syndrome. (2010)
  7. Van Kuppeveld FJM et al. Prevalence of xenotropic murine leukaemia virus-related virus in patients with chronic fatigue syndrome in the Netherlands: retrospective analysis of samples from an established cohort. (2010)
  8. Lombardi VC et al. Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome. (2009)

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